Keywords
antioxidantes naturales
subproductos agroindustriales
bioeconomía territorial
alimentos funcionales
How to Cite
Abstract
This editorial explores the potential of antioxidant bioactive peptides as a tool for fostering sustainable, health-promoting, and economically viable production systems, aligned with Sustainable Development Goals (SDGs 3, 9, and 12). Drawing on recent scientific literature, it highlights the growing interest in natural antioxidants derived from agro-industrial by-products, emphasizing their applications in the food, nutraceutical, and cosmetic industries. The article examines the functional properties of these peptides, their ability to mitigate oxidative processes, and the structural and enzymatic factors influencing their bioactivity. It also stresses the strategic value of rural and agricultural regions for developing localized bioeconomies through waste valorization technologies. Finally, the editorial addresses the main technical and regulatory challenges that limit the widespread use of bioactive peptides, suggesting that intensified research efforts and robust territorial networks of science, technology, and innovation are key to advancing the design, formulation, and clinical validation of these functional compounds.
References
Bhandari, D., Rafiq, S., Gat, Y., Gat, P., Waghmare, R., & Kumar, V. (2020). A Review on Bioactive Peptides: Physiological Functions, Bioavailability and Safety. International Journal of Peptide Research and Therapeutics, 26(1), 139–150. https://doi.org/10.1007/s10989-019-09823-5
Bidram, M., & Ganjalikhany, M. R. (2024). Bioactive peptides from food science to pharmaceutical industries: Their mechanism of action, potential role in cancer treatment and available resources. Heliyon, 10(23), e40563. https://doi.org/10.1016/j.heliyon.2024.e40563
Deng, Y., Butré, C. I., & Wierenga, P. A. (2018). Influence of substrate concentration on the extent of protein enzymatic hydrolysis. International Dairy Journal, 86, 39–48. https://doi.org/10.1016/J.IDAIRYJ.2018.06.018
Di Bernardini, R., Harnedy, P., Bolton, D., Kerry, J., O’Neill, E., Mullen, A.M., Hayes, M., 2011. Antioxidant and antimicrobial peptidic hydrolysates from muscle protein sources and by-products. Food Chem. 124, 1296–1307. doi:10.1016/j.foodchem.2010.07.004
Du, Z., & Li, Y. (2022). Review and perspective on bioactive peptides: A roadmap for research, development, and future opportunities. Journal of Agriculture and Food Research, 9, 100353. https://doi.org/https://doi.org/10.1016/j.jafr.2022.100353
Felix, M., Cermeño, M., & FitzGerald, R. J. (2020). Influence of Hydrolysis on the Bioactive Properties and Stability of Chickpea-Protein-Based O/W Emulsions. Journal of Agricultural and Food Chemistry, 68(37), 10118–10127. https://doi.org/10.1021/acs.jafc.0c02427
Gao, R., Yu, Q., Shen, Y., Chu, Q., Chen, G., Fen, S., Yang, M., Yuan, L., McClements, D. J., & Sun, Q. (2021). Production, bioactive properties, and potential applications of fish protein hydrolysates: Developments and challenges. Trends in Food Science & Technology, 110, 687–699. https://doi.org/https://doi.org/10.1016/j.tifs.2021.02.031
Gómez, L.J., Figueroa, O.A., Zapata, J.E., 2013. Actividad Antioxidante de Hidrolizados Enzimáticos de Plasma Bovino Obtenidos por Efecto de Alcalasa® 2.4 L. Inf. Tecnológica 24, 33–42. doi:10.4067/S0718-07642013000100005
He, S., Franco, C., Zhang, W., 2013. Functions, applications and production of protein hydrolysates from fish processing co-products (FPCP). Food Res. Int. 50, 289–297. doi:10.1016/j.foodres.2012.10.031
Hyun, C.-K., & Shin, H.-K. (2000a). Utilization of bovine blood plasma proteins for the production of angiotensin I converting enzyme inhibitory peptides. Process Biochemistry, 36(1–2), 65–71. https://doi.org/10.1016/S0032-9592(00)00176-X
Kanaujia, K. A., Wagh, S., Pandey, G., Phatale, V., Khairnar, P., Kolipaka, T., Rajinikanth, P. S., Saraf, S. A., Srivastava, S., & Kumar, S. (2025). Harnessing marine antimicrobial peptides for novel therapeutics: A deep dive into ocean-derived bioactives. International Journal of Biological Macromolecules, 307(Part 3), 142158. https://doi.org/10.1016/j.ijbiomac.2025.142158
Kandi, S., Inbaraj, B. S., & Chen, B.-H. (2021). Recent developments on production, purification and biological activity of marine peptides. Food Research International, 147, 110468. https://doi.org/10.1016/j.foodres.2021.110468
Korhonen, H., Pihlanto, A., 2006. Bioactive peptides: Production and functionality. Int. Dairy J., 4th NIZO Dairy Conference - Prospects for Health, Well-being and Safety4th NIZO Dairy Conference - Prospects for Health, Well-being and Safety 16, 945–960. doi:10.1016/j.idairyj.2005.10.012
Liu, Q., Kong, B., Xiong, Y. L., & Xia, X. (2010). Antioxidant activity and functional properties of porcine plasma protein hydrolysate as influenced by the degree of hydrolysis. Food Chemistry, 118(2), 403–410. https://doi.org/10.1016/J.FOODCHEM.2009.05.013
Rani, S., Pooja, K., & Pal, G. K. (2018). Exploration of rice protein hydrolysates and peptides with special reference to antioxidant potential: Computational derived approaches for bio-activity determination. Trends in Food Science & Technology, 80, 61–70. https://doi.org/https://doi.org/10.1016/j.tifs.2018.07.013
Sabeena Farvin, K. H., Andersen, L. L., Nielsen, H. H., Jacobsen, C., Jakobsen, G., Johansson, I., & Jessen, F. (2014). Antioxidant activity of Cod (Gadus morhua) protein hydrolysates: In vitro assays and evaluation in 5% fish oil-in-water emulsion. Food Chemistry, 149, 326–334. https://doi.org/10.1016/J.FOODCHEM.2013.03.075
Sarmadi, B.H., Ismail, A., 2010. Antioxidative peptides from food proteins: A review. Peptides 31, 1949–1956. doi:10.1016/j.peptides.2010.06.020
Seo, H.-W., Jung, E.-Y., Go, G., Kim, G.-D., Joo, S.-T., & Yang, H.-S. (2015). Optimization of hydrolysis conditions for bovine plasma protein using response surface methodology. Food Chemistry, 185, 106–111. https://doi.org/https://doi.org/10.1016/j.foodchem.2015.03.133
Xu, B., Wang, X., Zheng, Y., Li, Y., Guo, M., & Yan, Z. (2022). Novel antioxidant peptides identified in millet bran glutelin-2 hydrolysates: Purification, in silico characterization and security prediction, and stability profiles under different food processing conditions. LWT, 164, 113634. https://doi.org/https://doi.org/10.1016/j.lwt.2022.113634
Zheng, L., Zhao, Y., Dong, H., Su, G., & Zhao, M. (2016). Structure–activity relationship of antioxidant dipeptides: Dominant role of Tyr, Trp, Cys and Met residues. Journal of Functional Foods, 21, 485–496. https://doi.org/https://doi.org/10.1016/j.jff.2015.12.003
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